Fibrous plaque prevents uniform lengthening as erection occurs. As the rest of the corpus cavernosum and corpus spongiosum lengthen, the penis bends toward the involved area.
The drawing is adapted from "Peyronie's Disease: Current Management" by James Fitken, M.D., and George T. Ho, M.D., Mount Carmel Health System, Columbus, Ohio, as it appeared in the August 1999 issue of American Family Physician magazine.
In the article, they say, "One possible medical regimen is 100 mg of vitamin E taken three times a day for a minimum of four months. Theoretically, this antioxidant will prevent further development of plaque, although studies have suggested that
it is no more effective than placebo. Injectable verapamil also has received some attention recently, although studies have either shown no statistical improvement over placebo or have been critically compromised by very small study size."