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From Phoenix5's Prostate Cancer Glossary
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hypercalcemia of malignancy

Abbreviations: HCM

Definition: Abbreviated HCM, it is a life-threatening condition that effects many cancer patients. It occurs when factors made by cancer cells over-stimulate osteoclasts, which are cells responsible for bone resorption. The over-stimulation results in an increased rate of bone breakdown and the release of excess calcium into the bloodstream. The kidneys are unable to cope with the excessively high calcium levels and the calcium remains in the blood, leading to complications such as dehydration, fatigue, nausea, vomiting, confusion and coma.

For more information: See osteoclast.


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Definitions are provided for education only and are not medical advice. Created exclusively for Phoenix5. © 2002 Phoenix5.